You should choose Southern Ketamine Clinics because you will receive the safest
monitored infusions and warm, compassionate care. You are never left alone in the room.
We are all highly trained and experienced anesthesia providers and ketamine has always
been an anesthesia drug. We are more comfortable administering higher doses of ketamine
which hopefully gives you more longevity in between boosters. Most importantly, however,
is that we have one of the best response rates to treatment not only in North Carolina but in
the country.
Anxiety, depression, bipolar disorder, suicidal ideation, PTSD, acute and chronic pain,
migraines, and neuropathy.
We’re different because we actually follow the science. We studied the research and
protocols and have based our practice on doing seven infusions over four weeks. This is to
“reset” the brain. Because we are anesthesia providers, we are much more comfortable in
administering higher doses of medication. Research tells us that by following the research
protocols, 70% of the population is going to respond positively to a dose range of .3 MG/KG
to .6 MG/KG. We generally start everyone at .6 MG/KG and titrate the dose as needed to
tailor each treatment to the individual patient. We have a 90% positive response rate. I
believe that ongoing studies will tell us we need to be giving more of the drug. We are also
different because we stay with each patient during each infusion. Patients find that very
comforting and they feel safe.
All scientific studies are based upon an IV administration of ketamine. We know that with IV
you have 100% bioavailability of the drug to the brain. IV administration compared with IM
injection bioavailability decreases to 70%, with nasal ketamine bioavailability decreases to
30%, and with oral lozenges bioavailability is a 10%. The data is clear that the patient needs
to receive enough ketamine to cause disassociation, which is an altered state of
consciousness or awareness. That cannot be achieved using lower doses or less
bioavailable forms of Ketamine. Also, attempting talk therapy at the appropriate doses to
cause dissociation is not fruitful and lowering the dose and/or bioavailability in order to
maintain conscious thought and communication does not achieve the dissociative state
which is the purpose of Ketamine. The science is clear that there are 24 hours of brain
plasticity after an infusion meaning the brain and cognition is receptive to talk therapy
during that window.
We attempt to keep our prices down simply so that we can help more people by making
treatment more affordable. There are no shortcuts. Our set price covers all the
medications, disposables, monitoring, IV supplies and Providers salaries. This is a medical
clinic. We do not try to sell you on our services, add on services for an additional charge, or
take you into an environment where immediate medical care is not available if needed.
Some of our clients have gotten assistance through outside agencies but that is highly
variable.
Ketamine is an anesthesia drug with both desired effects and side effects. We monitor you
because Ketamine can increase heart rate as well as increase blood pressure and for some
individuals it can increase anxiety. When we are in the room monitoring your vital signs, we
can treat all these side effects with various IV medications.
We are all certified registered nurse anesthetists with many years of experience. We all have
been utilizing ketamine in the operating room at higher dosages, so we are accustomed to
its side effect as well.
When we first started the clinic, we followed the data in the studies which included dosing
from .3 mg/kg to .6 MG/KG. We noticed about 70% response rate (the national average) at
our clinic and thought this could be better. At that time, we began starting everyone at .6
MG/KG and then would increase dosing tailored to the patient. We started having higher
success rates. It is my opinion that psychiatry offices dose in the box of .3 MG/KG to .6
MG/KG because they are not as comfortable handling the side effects of the anesthesia
drug.
Your therapist is more than welcome to attend the sessions with you. As we increase your
dosing for deeper disassociation you will not be able to carry on conversation. You have 24
hours of brain plasticity after each infusion, and we encourage patients to receive
counseling during that window. This means that your brain is receptive to different ways of
thinking.
You will be greeted by our front desk and make payment at that time. We won’t ask for
payment after you have been given mind altering medication. We will encourage you to
empty your bladder before we take you back to the treatment room. The metabolites of
ketamine can be an irritant to the bladder and the majority of patients have an urgency to
empty their bladder at the end of the infusion. If you empty your bladder prior to treatment,
we know that your bladder is not full, but it is the metabolites of the ketamine. You will have
a brief conversation with your provider where you can ask questions. We will gladly answer
any questions and address any concerns you may have. We then place an IV using pediatric
size needles and begin your infusion. An anti-nausea drug is given along with a small dose
of anti-anxiety medication if needed. We place monitors on you where we can monitor
blood pressure, heart rate, and your O2 saturation. Music is played in the background, but
you are welcome to listen to your own music. A blanket is offered, and the room lights are
dimmed. We will stay with you the entire time. Once we turn on the infusion pump it takes 8
to 10 minutes for you to feel the effects of the ketamine and you will continue to feel those
effects the next hour. When you hear the infusion pump alarm it simply means that your bag
is empty. At that time, you will gently come back to active consciousness. When we feel you
have adequately recovered, we will remove your monitors and remove your IV.
We encourage all patients to maintain their present therapist. Once patients arrive to us,
they have usually had years of therapy and are comfortable with their therapist.
Ketamine is an anesthesia drug and is cognitively impairing. While you may feel fine (or
great!) your judgment may still be impaired. That is why you are not allowed to drive.
The referral needs to come from a provider with prescriptive authority. They are not writing a
prescription for your ketamine but are referring you to our clinic. That would include an MD,
DO, PA, or a nurse practitioner. We receive referrals from all specialties of medicine.
The first infusion seemingly affects patients more profoundly than the infusions going
forward. Most clients will return home, have a quick meal, maybe a short nap and are able
to return to work. Of course, this depends upon what your job is if you would feel
comfortable doing that.
Again, it is about resetting the brain. We recommend seven infusions over four weeks. You
have three infusions in week one, two infusions in week two, and then weekly infusions for
the following two weeks. If you think about your brain as a marble rolling in a groove for
depression, we give ketamine, and it knocks the marble out of that groove onto level ground
and it will roll and roll. The marble will eventually go back and reset to the groove of
depression because that is the way your brain has been tracking for years. Ketamine is
simply knocking that marble out of the groove again and again and again until it doesn’t
reset.
National studies have told us that 70% to 71% of the population respond to ketamine
infusion therapy. The studies are based upon dosing from .3 MG/KG -.6 MG/KG. We
generally start everyone at.6 MG/KG and titrate up tailoring to each patient. Each patient will
complete a Beck Depression Inventory scale prior to beginning the induction series. We will
reassess prior to your seventh infusion. Tracking this data at our clinic we have seen a >90%
response rate.
In the past two years there have been a few insurance companies who have begun covering
these infusions in part or whole. We require our patients to pay for the infusions upfront. At
the end of the induction series or at the end of a booster we will supply you with a super bill.
The super bill has the appropriate CPT codes that the insurance company needs, and you
can supply this information to your insurance. Any monies that they are going to reimburse
comes back directly to you.
We book each individual patient for 90 minutes. We do the infusion over 45 minutes and
then it takes approximately 20 to 30 minutes for patients to feel like they can walk back to
the lobby and go home.
The two most common side effects to ketamine are nausea and headache. We administer
an antinausea medication to everyone and headache is usually treated with Tylenol or Advil.
People feel much more sedated and sleepy after the first infusion and generally will eat a
meal and spend the day watching TV or napping. As people continue during the induction
series they often find that they are less fatigued and able to get back to life more quickly. In
the beginning of the process it is not uncommon for people to experience ups and downs in
mood. But as you continue, those ups and downs will become less steep and less often.
That is the million-dollar question. At the end of the induction series we have people step
away and assess if they feel ketamine has been a benefit. If the answer to that question is
yes, we advise people that if the feelings that made you seek us out start emerge you come
back for a single infusion. This process can vary from three weeks to 12 months. We never
know when someone will need to return. What we find is that because we dose higher
patients are not back is often, and as they continue in the process they will be able to space
their booster infusions farther and farther out.